The paper is devoted to continuous frames and continuous Riesz basis in Hilbert C*-modules. We define a continuous Riesz basis in Hilbert C*-modules and investigate the relationship between a continuous Riesz basis and an L^2-independent Bessel mapping. Also, we show that a continuous frame is a continuous Riesz basis if and only if it is a Riesz-type frame. Finally, we give the relation between two continuous Riesz bases in Hilbert C*-modules.